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Neurologic symptoms,MRI findings,and lymphocyte phenotyping studies suggest that the patients may have been experiencing a chronic, immunologically mediated inflammatory process of the central nervous system.The active replication of HHV-6 most likely represents reactivation of latent infection,perhaps due to immunologic dysfunction.Our study did not directly address whether HHV-6,a lymphotropic and gliotropic virus, plays a role in producing the symptoms or the immunologic and neurologic dysfunction seen in this illness.Whether the findings in our patients,who came from a relatively small geographic area,will be generalizable to other patients with a similar syndrome remains to be seen. |
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